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Hydroxychloroquine is used in the treatment of arthritis to help relieve inflammation, swelling, stiffness, and joint pain and also to help control the symptoms of lupus erythematosus lupus; SLE. This medicine was originally used to prevent and to treat malaria. Hydroxychloroquine is usually taken twice daily. The pills are mg. The usual dose is 1 or 2 pills daily.

This medicine should be taken at the same time every day.

Hydroxychloroquine (Plaquenil) - Overview

It will take 1 to 2 months to begin working. Do not take more or less medicine than ordered. This medicine should be taken with food or milk. When you are taking Hydroxychloroquine, it is very important that your doctors know if you are taking any other medicine.

Product Profile

This includes prescription and non-prescription medicines as well as birth control pills, vitamins, and herbal supplements. For treatment of malaria in adults, the dosage is mg followed by mg after 6, 24 and 48 hours after initial dose. For treatment of lupus, the recommended dose is to mg daily. For treatment of rheumatoid arthritis in adults, the initial dose is to mg followed by a maintenance dose of to mg. Take this medicine for the full treatment period as prescribed by your health care professional. If Plaquenil completely controls the disease, talk to your doctor about reducing the dosage of the drug.

Health and Community Services

Never reduce the dosage without talking to your doctor first. Anti-malarial compounds such as Plaquenil need to be used in caution in patients with alcoholism. You should inform your doctor if you drink large amounts of alcohol. Alcohol abuse can affect your liver which can affect the way how Plaquenil works in body.

What Is Hydroxychloroquine Used For?

It is best to avoid taking alcohol with this medication. Plaquenil can lead to impairment of accommodation, dizziness and blurring of vision. Do not operate or drive heavy machinery until you know how Plaquenil affects you. The use of Plaquenil might result in little improvement of symptoms in 1 to 2 months. But optimal improvement occurs in 6 months.

How is Plaquenil Metabolized in Body? Plaquenil hydroychlorquine is metabolized in liver and its half-life is about 40 to 50 days. Plaquenil can cause mild to moderate side effects. However, some side effects can be serious and require immediate treatment. You should inform your health care provider about any of the side effects that you experience while taking Plaquenil. Some very common side effects of Plaquenil include nausea, stomach cramps and pain.


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Others include diarrhea, loss of appetite, vomiting, visual problems such as blurring of vision, difficulty focusing, seeing halos around lights especially at night, night blindness, visual field loss, change in eye color, difficulty reading, headache, rashes, itchy rash and nervousness. Some rare side effects include dizziness, hair loss, bleaching of hair, loss of skin pigment or increase in skin pigment, ringing in ears, decreased hearing, nerve and muscle disorders including tingling, numbness, burning pain, weakness, cramps and spasms. Side effects of unknown frequency include severe skin problem, severe breathing problem, increased sensitivity to sunlight, muscle weakness, permanent damage to vision, heart problems such as irregular heartbeat, chest pain, fainting, liver problems like jaundice, abdominal pain, convulsions, lowered blood cell count, psychosis, hallucinations, suicidal thoughts, low blood sugar and tremors.

These are not all the side effects of Plaquenil. In case of any unexpected effect, contact your health care provider immediately. How Safe Is Plaquenil? Hence, you should inform your doctor if you are pregnant. Plaquenil also passes into breast milk. You should tell your doctor if you are breast feeding before taking Plaquenil.

Sometimes, Plaquenil can lead to sever life threatening hypoglycemia low blood sugar with loss of consciousness. You should talk to your doctor if you have symptoms of sweating, shakiness, weakness, dizziness and fast heartbeat.

This medication prolongs QT interval heart rhythm condition that can potentially cause fast, irregular heartbeats. Consult your doctor immediately if you experience a sudden fainting spell.


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While taking Plaquenil, protect your skin from sun with appropriate clothing and sunscreen cream of minimum SPF Plaquenil has been used safely in combination with salicylates aspirin , non-steroidal anti-inflammatory drugs such as ibuprofen, methotrexate and corticosteroids. Do not take Plaquenil if you: Are allergic to hydroxychlorquine sulfate or any of the ingredients of Plaquenil.

Are pregnant or planning to become pregnant Are breast-feeding or planning to breast-feed Have retinopathy eye problem affecting the retina. Plaquenil can cause irreversible damage to the retina back of the eye where vision is formed. It is very important to have an eye exam before taking Plaquenil and then follow-up as needed while taking the drug.

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