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Inclusion Criteria: Healthy adults male or non-pregnant, non-lactating female 18 to 50 years of age inclusive at the time of screening. If the subject is female: Non-childbearing potential ie. Available to participate in all planned study visits and reachable by phone for duration of study approximately 4 months. Willing to comply with all protocol procedures and time commitments No plans to participate in another clinical research study for the duration of this study.

Subjects with a history of retinopathy, sickle cell disease or trait, psoriasis, or porphyria. Subjects who take certain prescribed or over the counter OTC concomitant medication including: ampicillin, antacids including kaolin , cimetidine, digoxin, ergot alkaloids, statins HMG-CoA reductase inhibitors , cyclosporine, warfarin, fluconazole, nelfinavir, or rifabutin, within 2 weeks of dosing start, and during the duration of the study. Are known or suspected of drinking too much alcohol for men, more than 28 standard alcohol drinks and for women more than 21 standard alcohol drinks per week standard drink is defined as a 12 oz beer, 5 oz glass of wine, or 1.

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