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Although Plaquenil was first used for preventing and treating Chloroquine sensitive types of malaria, doctors have found it beneficial as an anti inflammatory drug for those with arthritis, some symptoms of lupus, and other immune-mediated diseases. The generic alternative is not manufactured by the company that makes the brand product. The exact mechanism of how Plaquenil works as an anti-rheumatic drug is not entirely clear. However, when taken as directed, Plaquenil appears to inhibit the actions of inflammatory mediators, such as prostaglandins. This decreases inflammation in the affected joints.
For preventing malaria, Plaquenil is taken once a week for two weeks prior to entering any of the countries where malaria is prevalent.