Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: Healthy adults male or non-pregnant, non-lactating female 18 to 50 years of age inclusive at the time of screening. If the subject is female: Non-childbearing potential ie.

Available to participate in all planned study visits and reachable by phone for duration of study approximately 4 months. Willing to comply with all protocol procedures and time commitments No plans to participate in another clinical research study for the duration of this study. Subjects with a history of retinopathy, sickle cell disease or trait, psoriasis, or porphyria. Subjects who take certain prescribed or over the counter OTC concomitant medication including: ampicillin, antacids including kaolin , cimetidine, digoxin, ergot alkaloids, statins HMG-CoA reductase inhibitors , cyclosporine, warfarin, fluconazole, nelfinavir, or rifabutin, within 2 weeks of dosing start, and during the duration of the study.

Are known or suspected of drinking too much alcohol for men, more than 28 standard alcohol drinks and for women more than 21 standard alcohol drinks per week standard drink is defined as a 12 oz beer, 5 oz glass of wine, or 1. Subjects who have donated more than mL males or mL females blood in the previous 12 months, including the maximum volume of blood mL to be taken in this study.

Subjects who are currently enrolled in another study involving an investigational product, or if recently involved in another clinical trial which has ended, have not received any investigational products within the past 3 months or 5 half-lives whichever is longer from the time of screening. Any history of malaria infection in the past 3 years. History of travel to malaria endemic areas in the 3 months prior to day of challenge, or plans to travel to malaria endemic areas during the duration of the study 56 days post challenge. Any other significant finding that in the opinion of the PI would increase the risk of having an adverse outcome from participating in this study.

Contacts and Locations.

Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.

More Information. Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya. Clin Infect Dis. Biswas S.

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In-vitro antimalarial activity of azithromycin against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. J Postgrad Med.

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A multicenter study of azithromycin, alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India. J Infect Dis. Epub Apr Randomized dose-ranging controlled trial of AQ, a candidate antimalarial, and chloroquine in healthy volunteers. It's also described as "the saltwater aquarium wonder drug" and is the drug of choice for many public aquariums, including the Georgia Aquarium. Both are oral prescription drugs that have been used for the treatment of malaria and certain inflammatory conditions since the s.

Chloroquine has been used for malaria treatment and chemoprophylaxis. Hydroxychloroquine is used for the treatment of rheumatoid arthritis, systemic lupus erythematosus, and porphyria cutanea tarda, according to the Centers for Disease Control and Prevention CDC. The drugs can also have major side effects, a reason doctors don't want to give them out without scientific evidence of their value, even during a global pandemic.

It also plans to be the nation's first state to try to heal critically ill patients using the antibodies extracted from the plasma of individuals who have recovered from the virus. The federal government cleared the way for New York to experiment with the malaria and lupus drug hydroxychloroquine and the antibiotic Zithromax generic name azithromycin as a treatment for COVID, Gov.

Andrew Cuomo said over the weekend. Currently, clinical management for those who have COVID includes infection prevention, control measures and supportive care, such as supplementary oxygen and ventilatory support in the most dire of cases. However, the CDC notes that there are a number of drugs that have been approved for other ailments as well as several investigational drugs that are being studied in clinical trials taking place across the world.

Those drugs include hydroxycloroquine and azithromycin. Hydroxychloroquine and chloroquine are oral prescription drugs that have been used for treatment of malaria and certain inflammatory conditions like lupus. According to the CDC, chloroquine has been used for malaria treatment and chemoprophylaxis, meanwhile hydroxychloroquine is also used for treatment of rheumatoid arthritis, systemic lupus erythematosus and porphyria cutanea tarda.

Chloroquine or hydroxychloroquine are currently recommended for the treatment of hospitalized COVID patients in several countries. The main concerns of using either chloroquine and hydroxychloroquine is cardiotoxicity, especially prolonged QT syndrome, which is a heart rhythm condition that can cause fast, chaotic heartbeats. This concern is particularly more acute in patients with underlying health issues and immunosuppression, according to the CDC.

Because of these concerns, CDC urges caution when considering these drugs in patients with chronic medical conditions or those who are receiving medications that might interact and cause arrythmias -- problems with the heartbeat's rate or rhythm.