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Coronavirus Minneapolis St. Stores banning reusable bags, putting up shields to keep workers safe. Minnesota Department of Corrections seeks to stop in-person hearings for inmates. Loons supporters group blasts team for telling idled workers to find other jobs. Schafer: Stay home, Minnesota, and wait for the economic payoff to come. Twin Cities apartment developers worry shutdown could idle projects worth billions.

Singing the concert cancellation blues? Get your live music fix with these 25 films. Charges: Central Minnesota burglar steals, badly damages pristine classic Thunderbird. Campfires, s'mores, canoeing and booze: Welcome to summer camp for adults. By Joe Carlson Star Tribune. More from Star Tribune. Coronavirus Walz to Minnesota: 'Stay at home' 40 minutes ago.

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WHO launches global megatrial of the four most promising coronavirus treatments | Science | AAAS

Coronavirus Map: Tracking coronavirus in Minnesota pm. Coronavirus What you need to know about Minnesota's 'stay-at-home' order 32 minutes ago. More From Star Tribune. Scientists have suggested dozens of existing compounds for testing, but WHO is focusing on what it says are the four most promising therapies: an experimental antiviral compound called remdesivir; the malaria medications chloroquine and hydroxychloroquine; a combination of two HIV drugs, lopinavir and ritonavir; and that same combination plus interferon-beta, an immune system messenger that can help cripple viruses.

The participant has to sign an informed consent form that is scanned and sent to WHO electronically. After the physician states which drugs are available at his or her hospital, the website will randomize the patient to one of the drugs available or to the local standard care for COVID Physicians will record the day the patient left the hospital or died, the duration of the hospital stay, and whether the patient required oxygen or ventilation, she says.

The design is not double-blind, the gold standard in medical research, so there could be placebo effects from patients knowing they received a candidate drug. But WHO says it had to balance scientific rigor against speed. We think that randomized evidence is the best way to do that.

That trial will test the same drugs, with the exception of chloroquine. Other countries or groups of hospitals could organize add-on studies as well, Heneo-Restrepo says.

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The list of drugs to test was first put together for WHO by a panel of scientists who have been assessing the evidence for candidate therapies since January, Heneo-Restrepo says. The new coronavirus is giving this compound a second chance to shine. Originally developed by Gilead Sciences to combat Ebola and related viruses, remdesivir shuts down viral replication by inhibiting a key viral enzyme, the RNA-dependent RNA polymerase. Researchers tested remdesivir last year during the Ebola outbreak in the Democratic Republic of the Congo, along with three other treatments.

Two others did. A Californian patient who received remdesivir—and who doctors thought might not survive— recovered as well. Jiang particularly likes that high doses of the drug can likely be given without causing toxicities. However, it may be much more potent if given early in an infection, like most other drugs, says Stanley Perlman, a coronavirus researcher at the University of Iowa.

Experimental treatment strategies being tested by a large WHO study and other clinical trials attempt to interfere with different steps numbered in the coronavirus replication cycle. Springfield Food Co-op is looking for a full-time Wellness Manager to join our management team. We are looking for candidates with deep knowledge of holistic health, including vitamins, herbs, supplements, teas, probiotics, etc. This candidate will provide top notch customer service to a customer base that expects to find their holistic health supports here.

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Looking to lead an exciting team of service and sustainability-oriented meat professionals? Want to exercize and grow your industry knowledge, lead innovations, and be part of an excellent team of managers at one of the biggest Co-op stores in the country? We are searching for a Front-End Manager. This position supervises all operations of the Front-End Department.

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They are responsible for the hiring, supervising, scheduling, training, and mentoring of all Front-End staff. This is a full-time "on the floor" position as the Front-End Manager is responsible for the overall customer experience and ensuring that all department staff feel supported in their roles and are providing exceptional customer service.

This is also a closing position you will be responsible for closing the store so the hours are currently from pm to pm. We are searching for a Produce Department Manager. This person supervises one buyer along with several department team members. They are responsible for scheduling, training, managing operations, and upholding performance and efficiency standards.

General managers, multi-unit regional managers, retail food managers and grocery business consultants: Are you interested in work that allows you to support the success and social impact of retail food co-ops?

Would you like to apply your financial and retail expertise to supporting socially responsible, independent, and community-owned grocery stores? Are you a strong communicator with outstanding customer service? Skip to main content. Section - Any -. Name Enter a comma separated list of user names. Include archived content No Yes Only archived content. No reasonable limit to length.

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