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He added: 'All patients will receive the standard full medical care, regardless of which treatment group they are placed in. Adult inpatients who have tested positive for COVID in NHS hospitals, and not been excluded for medical reasons, will be offered the chance to take part in the trial. Participants will be allocated at random by computer to receive one of the two drugs being studied or no additional medication.

This will enable researchers to see whether any of the possible new treatments are more or less effective than those currently used for patients with the virus.

Chloroquine, or hydroxychloroquine, has been used to treat malaria since 1944.

Martin Landray, professor of medicine and epidemiology at the Nuffield department of population health, and deputy chief investigator, added: 'The streamlined design of this clinical trial allows consenting patients to be enrolled in large numbers easily and without compromising patient safety or adding significantly to the workload of busy hospitals and their staff.

NHS hospitals are coming under growing pressure to use experimental drugs to try and treat patients infected with the coronavirus. Doctors and pharmaceutical firms around the world are scrambling to find a drug that can stop the deadly virus, which has now killed more than 8, people. Medicines already in use for conditions ranging from HIV to rheumatoid arthritis, malaria, the flu and even Ebola are serious contenders and are being tested to see how they could help patients infected with COVID The Government has refused to confirm if any are being tested out on the 2, coronavirus patients in the UK — the NHS advises anyone with troublesome symptoms to take paracetamol and rest at home unless they feel life-threateningly ill.

But its medicines regulator last month banned companies from exporting three drugs — for HIV and malaria — in a bid to protect the UK's stocks of them. All three have been used in experimental treatments by doctors in China, raising the prospect of Britain doing the same. Here, MailOnline reveals some of the drugs that experts believe have potential. Chloroquine phosphate Malaria. Experts at the University of Palermo in Italy, as well as a team in Israel, collated the research on the drug in treating the coronavirus.

In their report, they claimed officials in the Netherlands already suggest treating critically-ill patients with the drug. The Wuhan Institute of Virology — in the city where the crisis began — claimed the drug was 'highly effective' in petri dish tests. Tests by those researchers, as well as others, showed it has the power to stop the virus replicating in cells, and taking hold in the body. Twenty-three clinical trials on the drug are already underway on patients in China, and one is planned in the US and another in South Korea. University of Minnesota experts are planning to test whether the drug — sometimes given to treat lupus and arthritis — prevents the progression of COVID Chloroquine was prescribed around 46, times in in the UK — but it is also available over-the-counter from pharmacies without a prescription.

It is sold under the brand name Arlan. Professor Robin May, an infectious disease specialist at Birmingham University, said the safety profile of the drug is 'well-established'.

Coronavirus UK: Potentially effective malaria drug running out | Daily Mail Online

He added: 'It is cheap and relatively easy to manufacture, so it would be fairly easy to accelerate into clinical trials and, if successful, eventually into treatment. Professor May suggested chloroquine may work by altering the acidity of the area of cells that it attacks, making it harder for the virus to replicate. Hydroxychloroquine Malaria. Chinese scientists investigating the other form of chloroquine penned a letter to a prestigious journal saying its 'less toxic' derivative may also help. In the comment to Cell Discovery — owned by publisher Nature, they said it shares similar chemical structures and mechanisms.

The team of experts added: 'It is easy to conjure up the idea that hydroxychloroquine may be a potent candidate to treat infection by SARS-CoV But the Wuhan Institute of Virology scientists admitted they are still lacking evidence to prove it is as effective as chloroquine phosphate. Hydroxychloroquine, sold under the brand name Plaquenil, causes side effects such as skin rashes, nausea, diarrhoea and headaches. Drug giant Sanofi carried out a study on 24 patients, which the French government described as 'promising'. Results showed three quarters of patients treated with the drug were cleared of the virus within six days.

None of the placebo group were treated. Favipiravir flu. Favipiravir is the active ingredient in a flu drug called Avigan which is sold in Japan. Doctors in China have claimed it was 'clearly effective' in patients with the coronavirus after they gave it to 80 people in the cities of Wuhan and Shenzen. They said it sped up patients' recovery, reduced lung damage and did not cause any obvious side effects. It is also used to treat yellow fever and foot-and-mouth.

According to local media, patients who were given the medicine in Shenzhen had negative results for the coronavirus an average of four days after being diagnosed. This compared with 11 days for those who were not treated with the drug. It is not clear what the results were of the trials in Wuhan, the worst-hit part of China. The drug is an anti-viral medication which neutralises a vital enzyme that viruses use to reproduce. It is not used by the NHS. It's produced by the Japanese company Fujifilm Toyama Chemical. Remdesivir Ebola. Remdesivir is an anti-viral drug that works in essentially the same way as favipiravir — by crippling the RNA polymerase enzyme, stopping a virus from reproducing.

It was pushed aside, however, when other, better candidates emerged. Doctors writing in a study led by the Wuhan Institute of Virology, published in the prestigious scientific journal Nature last month, said: 'Our findings reveal that remdesivir [is] highly effective in the control of nCoV infection in vitro. They added that, since the drug is proven to be safe in humans, it 'should be assessed in human patients suffering from the novel coronavirus disease'.

Sarilumab Rheumatoid arthritis. Sarilumab, a rheumatoid arthritis drug which is marketed as Kevzara in the US, is set to be trialled on patients in the US. Sarilumab, a rheumatoid arthritis drug which is marketed as Kevzara and is available to be prescribed on the NHS, is set to be trialled on patients in the US. Pharmaceutical companies Sanofi and Regeneron plan to give the medication to people with the coronavirus to see if it can help calm their immune response.

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The drug works by blocking part of the immune system which can cause inflammation, or swelling, which is overactive in people with rheumatoid arthritis. What is the coronavirus? A coronavirus is a type of virus which can cause illness in animals and people. Viruses break into cells inside their host and use them to reproduce itself and disrupt the body's normal functions.

Coronaviruses are named after the Latin word 'corona', which means crown, because they are encased by a spiked shell which resembles a royal crown. The coronavirus from Wuhan is one which has never been seen before this outbreak. The name stands for Severe Acute Respiratory Syndrome coronavirus 2. Experts say the bug, which has killed around one in 50 patients since the outbreak began in December, is a 'sister' of the SARS illness which hit China in , so has been named after it.

The disease that the virus causes has been named COVID, which stands for coronavirus disease Dr Helena Maier, from the Pirbright Institute, said: 'Coronaviruses are a family of viruses that infect a wide range of different species including humans, cattle, pigs, chickens, dogs, cats and wild animals.

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Four of these cause a mild common cold-type illness, but since there has been the emergence of two new coronaviruses that can infect humans and result in more severe disease Severe acute respiratory syndrome SARS and Middle East respiratory syndrome MERS coronaviruses. The animal origin of the new coronavirus is not yet known. The first human cases were publicly reported from the Chinese city of Wuhan, where approximately 11million people live, after medics first started publicly reporting infections on December By January 8, 59 suspected cases had been reported and seven people were in critical condition.

Tests were developed for the new virus and recorded cases started to surge. The first person died that week and, by January 16, two were dead and 41 cases were confirmed.


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The next day, scientists predicted that 1, people had become infected, possibly up to 7, Where does the virus come from? According to scientists, the virus almost certainly came from bats. Coronaviruses in general tend to originate in animals — the similar SARS and MERS viruses are believed to have originated in civet cats and camels, respectively. The first cases of COVID came from people visiting or working in a live animal market in Wuhan, which has since been closed down for investigation.

Although the market is officially a seafood market, other dead and living animals were being sold there, including wolf cubs, salamanders, snakes, peacocks, porcupines and camel meat.


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However, there were not many bats at the market so scientists say it was likely there was an animal which acted as a middle-man, contracting it from a bat before then transmitting it to a human. It has not yet been confirmed what type of animal this was. Dr Michael Skinner, a virologist at Imperial College London, was not involved with the research but said: 'The discovery definitely places the origin of nCoV in bats in China. So far the fatalities are quite low. Why are health experts so worried about it? Experts say the international community is concerned about the virus because so little is known about it and it appears to be spreading quickly.

It is similar to SARS, which infected 8, people and killed nearly in an outbreak in Asia in , in that it is a type of coronavirus which infects humans' lungs. Another reason for concern is that nobody has any immunity to the virus because they've never encountered it before. This means it may be able to cause more damage than viruses we come across often, like the flu or common cold.

Coronavirus outbreak: Trump says FDA has approved Chloroquine for COVID-19 testing - FULL

Speaking at a briefing in January, Oxford University professor, Dr Peter Horby, said: 'Novel viruses can spread much faster through the population than viruses which circulate all the time because we have no immunity to them. Here we're talking about a virus where we don't understand fully the severity spectrum but it's possible the case fatality rate could be as high as two per cent. If the death rate is truly two per cent, that means two out of every patients who get it will die. But that's the current circumstance we're in. How does the virus spread? The illness can spread between people just through coughs and sneezes, making it an extremely contagious infection.

And it may also spread even before someone has symptoms. It is believed to travel in the saliva and even through water in the eyes, therefore close contact, kissing, and sharing cutlery or utensils are all risky. It can also live on surfaces, such as plastic and steel, for up to 72 hours, meaning people can catch it by touching contaminated surfaces.

Originally, people were thought to be catching it from a live animal market in Wuhan city. But cases soon began to emerge in people who had never been there, which forced medics to realise it was spreading from person to person. What does the virus do to you? What are the symptoms? Once someone has caught the COVID virus it may take between two and 14 days, or even longer, for them to show any symptoms — but they may still be contagious during this time. If and when they do become ill, typical signs include a runny nose, a cough, sore throat and a fever high temperature.

The vast majority of patients will recover from these without any issues, and many will need no medical help at all. In a small group of patients, who seem mainly to be the elderly or those with long-term illnesses, it can lead to pneumonia.

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Pneumonia is an infection in which the insides of the lungs swell up and fill with fluid.

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